Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice

Increased oxidative stress underlies a variety of diseases, including diabetes. Here, we show that the cobalamin/vitamin B(12) analog cobinamide is a strong and multifaceted antioxidant, neutralizing superoxide, hydrogen peroxide, and peroxynitrite, with apparent rate constants of 1.9 × 10(8), 3.7 ×...

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Detalles Bibliográficos
Autores principales: Chang, Stephen, Tat, John, China, Shyamsundar Pal, Kalyanaraman, Hema, Zhuang, Shunhui, Chan, Adriano, Lai, Cassandra, Radic, Zoran, Abdel-Rahman, Engy A, Casteel, Darren E, Pilz, Renate B, Ali, Sameh S, Boss, Gerry R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578022/
https://www.ncbi.nlm.nih.gov/pubmed/36276587
http://dx.doi.org/10.1093/pnasnexus/pgac191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578022/
https://www.ncbi.nlm.nih.gov/pubmed/36276587
http://dx.doi.org/10.1093/pnasnexus/pgac191

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