An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria

BACKGROUND: Evidence supports therapeutic drug monitoring of polymyxin B, but clinical data for establishing an area under the concentration–time curve across 24 h at steady state (AUC(ss,24 h)) threshold are still limited. This study aimed to examine exposure–response/toxicity relationship for poly...

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Detalles Bibliográficos
Autores principales: Yang, Jing, Liu, Shaohua, Lu, Jingli, Sun, Tongwen, Wang, Peile, Zhang, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578216/
https://www.ncbi.nlm.nih.gov/pubmed/36258197
http://dx.doi.org/10.1186/s13054-022-04195-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578216/
https://www.ncbi.nlm.nih.gov/pubmed/36258197
http://dx.doi.org/10.1186/s13054-022-04195-7

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