Protective effect of Secukinumab on severe sepsis model rats by neutralizing IL-17A to inhibit IKBα/NFκB inflammatory signal pathway

Secukinumab is a specific neutralizing antibody for IL-17A. At present, numerous studies have confirmed the important role of IL-17A in sepsis, but the role of secukinumab in sepsis has not been studied. The present study explored the protective effect and underlying mechanism of secukinumab in seve...

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Detalles Bibliográficos
Autores principales: Wang, Xingsheng, Zhang, Xinxin, Sun, Li, Gao, Guangsheng, Li, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578221/
https://www.ncbi.nlm.nih.gov/pubmed/36253831
http://dx.doi.org/10.1186/s40001-022-00845-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578221/
https://www.ncbi.nlm.nih.gov/pubmed/36253831
http://dx.doi.org/10.1186/s40001-022-00845-2

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