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The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment
Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and maintaining genome stability during cell division. Based on their distinct functions in cell cycle control, cell cy...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578258/ https://www.ncbi.nlm.nih.gov/pubmed/36253861 http://dx.doi.org/10.1186/s13045-022-01360-x |