Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that modify macrophage susceptibility to Hc infection, g...

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Detalles Bibliográficos
Autores principales: Cohen, Allison, Jeng, Edwin E., Voorhies, Mark, Symington, Jane, Ali, Nebat, Rodriguez, Rosa A., Bassik, Michael C., Sil, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578593/
https://www.ncbi.nlm.nih.gov/pubmed/36174103
http://dx.doi.org/10.1371/journal.ppat.1010237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578593/
https://www.ncbi.nlm.nih.gov/pubmed/36174103
http://dx.doi.org/10.1371/journal.ppat.1010237

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