Cargando…

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that modify macrophage susceptibility to Hc infection, g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cohen, Allison, Jeng, Edwin E., Voorhies, Mark, Symington, Jane, Ali, Nebat, Rodriguez, Rosa A., Bassik, Michael C., Sil, Anita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578593/ https://www.ncbi.nlm.nih.gov/pubmed/36174103 http://dx.doi.org/10.1371/journal.ppat.1010237

Ejemplares similares

Recyclable CRISPR/Cas9 mediated gene disruption and deletions in Histoplasma
por: Joehnk, Bastian, et al.
Publicado: (2023)

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
por: Han, Kyuho, et al.
Publicado: (2017)

Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis
por: Azimova, Dinara, et al.
Publicado: (2022)

Experimental annotation of the human pathogen Histoplasma capsulatum transcribed regions using high-resolution tiling arrays
por: Voorhies, Mark, et al.
Publicado: (2011)

A Temperature-Responsive Network Links Cell Shape and Virulence Traits in a Primary Fungal Pathogen
por: Beyhan, Sinem, et al.
Publicado: (2013)

N-acetylglucosamine (GlcNAc) Triggers a Rapid, Temperature-Responsive Morphogenetic Program in Thermally Dimorphic Fungi
por: Gilmore, Sarah A., et al.
Publicado: (2013)

Genome-Wide Reprogramming of Transcript Architecture by Temperature Specifies the Developmental States of the Human Pathogen Histoplasma
por: Gilmore, Sarah A., et al.
Publicado: (2015)

Correction: Genome-Wide Reprogramming of Transcript Architecture by Temperature Specifies the Developmental States of the Human Pathogen Histoplasma
por: Gilmore, Sarah A., et al.
Publicado: (2021)

Establishment of CRISPR-Cas9 system in Bifidobacteria animalis AR668
por: Li, Jiao, et al.
Publicado: (2023)

An Introduction to CRISPR-Mediated Genome Editing in Fungi
por: Vyas, Valmik K., et al.
Publicado: (2019)

Systematic comparison of CRISPR-Cas9 and RNAi screens for essential genes
por: Morgens, David W, et al.
Publicado: (2016)

$^{40}Ti \beta$ decay and the neutrino capture cross section of $^{40}Ar$
por: Trinder, W, et al.
Publicado: (1997)

Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum
por: Rodriguez, Lauren, et al.
Publicado: (2019)

Retraction: Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum
por: Rodriguez, Lauren, et al.
Publicado: (2023)

The total nuclear capture rates for negative muons in $^{132}Xe$ and $^{40}Ar$ isotopes
por: Mamedov, T N
Publicado: (1998)

Macrophages at work: phagocytosis of urinary fungi
por: Tesser Poloni, José Antonio, et al.
Publicado: (2013)

$^{43}$Ar and $^{44}$Ar
por: Hudis, J, et al.
Publicado: (1970)

$^{43}Ar$ and $^{44}Ar$
por: Hudis, J, et al.
Publicado: (1970)

To Be(Ar) Or Not to Be(Ar) – Jones Dilemma?
por: Andrews, Nicholas A., et al.
Publicado: (2022)

Increased AR expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2
por: Labaf, Maryam, et al.
Publicado: (2022)

The CRISPR/Cas9 System for Targeted Genome Engineering in Free-Living Fungi: Advances and Opportunities for Lichenized Fungi
por: Shanmugam, Karthik, et al.
Publicado: (2019)

Foreign DNA capture during CRISPR–Cas adaptive immunity
por: Nuñez, James K., et al.
Publicado: (2015)

Genome Organization and Copy-Number Variation Reveal Clues to Virulence Evolution in Coccidioides posadasii
por: Dubin, Claire A., et al.
Publicado: (2022)

A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi
por: Nødvig, Christina S., et al.
Publicado: (2015)

Practical guidance for the implementation of the CRISPR genome editing tool in filamentous fungi
por: Kwon, Min Jin, et al.
Publicado: (2019)

CRISPR-based transcriptional activation tool for silent genes in filamentous fungi
por: Mózsik, László, et al.
Publicado: (2021)

Applications of CRISPR/Cas9 in the Synthesis of Secondary Metabolites in Filamentous Fungi
por: Jiang, Chunmiao, et al.
Publicado: (2021)

Co-expression and clinical utility of AR-FL and AR splice variants AR-V3, AR-V7 and AR-V9 in prostate cancer
por: Wüstmann, Neele, et al.
Publicado: (2023)

On atmospheric $^{39}Ar$ and $^{42}Ar$ abundance
por: Cennini, P, et al.
Publicado: (1995)

New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi
por: Vyas, Valmik K., et al.
Publicado: (2018)

CRISPR/Cas9 genome editing technology in filamentous fungi: progress and perspective
por: Song, Runjie, et al.
Publicado: (2019)

Progress and Challenges: Development and Implementation of CRISPR/Cas9 Technology in Filamentous Fungi
por: Wang, Qiang, et al.
Publicado: (2019)

Correction to: Practical guidance for the implementation of the CRISPR genome editing tool in filamentous fungi
por: Kwon, Min Jin, et al.
Publicado: (2019)

Application progress of CRISPR/Cas9 genome-editing technology in edible fungi
por: Zhang, Yan, et al.
Publicado: (2023)

The dynamics of the rapid neutron capture process
por: Cameron, A G W, et al.
Publicado: (1970)

The WOPR family protein Ryp1 is a key regulator of gene expression, development, and virulence in the thermally dimorphic fungal pathogen Coccidioides posadasii
por: Mandel, M. Alejandra, et al.
Publicado: (2022)

Dissection of the epoxyjanthitrem pathway in Epichloë sp. LpTG-3 strain AR37 by CRISPR gene editing
por: Miller, Taryn A., et al.
Publicado: (2022)

Capturing the multifaceted function of adipose tissue macrophages
por: Matz, Alyssa J., et al.
Publicado: (2023)

Techniques for placement of grid and strip electrodes for intracranial epilepsy surgery monitoring: Pearls and pitfalls
por: Voorhies, Jason M., et al.
Publicado: (2013)

Ár njöt'i ar hai = El color de la tierra
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9884s1pnrqvof0h89eu6jbuvnu