Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis

Serine palmitoyl transferase (SPT), the rate-limiting enzyme in the de novo synthesis of sphingolipids (SL), is needed for embryonic development, physiological homeostasis, and response to stress. The functions of de novo SL synthesis in vascular endothelial cells (EC), which line the entire circula...

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Detalles Bibliográficos
Autores principales: Kuo, Andrew, Checa, Antonio, Niaudet, Colin, Jung, Bongnam, Fu, Zhongjie, Wheelock, Craig E, Singh, Sasha A, Aikawa, Masanori, Smith, Lois E, Proia, Richard L, Hla, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578713/
https://www.ncbi.nlm.nih.gov/pubmed/36197001
http://dx.doi.org/10.7554/eLife.78861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578713/
https://www.ncbi.nlm.nih.gov/pubmed/36197001
http://dx.doi.org/10.7554/eLife.78861

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