GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-resistant models of PCa both in vitr...

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Detalles Bibliográficos
Autores principales: Cordova, Ricardo A, Misra, Jagannath, Amin, Parth H, Klunk, Anglea J, Damayanti, Nur P, Carlson, Kenneth R, Elmendorf, Andrew J, Kim, Hyeong-Geug, Mirek, Emily T, Elzey, Bennet D, Miller, Marcus J, Dong, X Charlie, Cheng, Liang, Anthony, Tracy G, Pili, Roberto, Wek, Ronald C, Staschke, Kirk A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578714/
https://www.ncbi.nlm.nih.gov/pubmed/36107759
http://dx.doi.org/10.7554/eLife.81083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578714/
https://www.ncbi.nlm.nih.gov/pubmed/36107759
http://dx.doi.org/10.7554/eLife.81083

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