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Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke

The aim of this study is to evaluate the value of the triglyceride-glucose (TyG) index and the risk of large artery atherosclerotic (LAA) stroke. Information on general demographic and clinical characteristics, magnetic resonance angiography (MRA) examination, and blood biochemical index determinati...

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Autores principales: Jiang, Mingfei, Wu, Huan, Zhang, Huiping, Su, Fan, Cao, Lei, Ren, Xia, Tatenda, Grace, Hu, Jian, Cheng, Mingjia, Wen, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578805/
https://www.ncbi.nlm.nih.gov/pubmed/36304978
http://dx.doi.org/10.1155/2022/5191581
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author Jiang, Mingfei
Wu, Huan
Zhang, Huiping
Su, Fan
Cao, Lei
Ren, Xia
Tatenda, Grace
Hu, Jian
Cheng, Mingjia
Wen, Yufeng
author_facet Jiang, Mingfei
Wu, Huan
Zhang, Huiping
Su, Fan
Cao, Lei
Ren, Xia
Tatenda, Grace
Hu, Jian
Cheng, Mingjia
Wen, Yufeng
author_sort Jiang, Mingfei
collection PubMed
description The aim of this study is to evaluate the value of the triglyceride-glucose (TyG) index and the risk of large artery atherosclerotic (LAA) stroke. Information on general demographic and clinical characteristics, magnetic resonance angiography (MRA) examination, and blood biochemical index determination were obtained. Based on age stratification, three models to evaluate the odds ratio (OR) and the 95% confidence interval (95% CI) were employed to determine the correlation between the TyG index and the risk of LAA stroke. The most effective TyG index threshold in predicting a high risk of LAA stroke was identified using receiver operating characteristic (ROC) curve analysis. Logistic regression verified the association between the risk of LAA stroke and the TyG index. Both with and without age stratification, logistic regression analysis showed that the TyG index was a significant predictor of the occurrence of LAA stroke (P < 0.05). The maximum Youden index for determining a high risk of LAA stroke was found at a TyG index of 4.60. The area under the ROC curve was 0.69 (95% CI: 0.646–0.742, P < 0.05), sensitivity was 78.0%, and specificity was 63.4%. An elevated TyG index was remarkably associated with a high risk of LAA stroke.
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spelling pubmed-95788052022-10-26 Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke Jiang, Mingfei Wu, Huan Zhang, Huiping Su, Fan Cao, Lei Ren, Xia Tatenda, Grace Hu, Jian Cheng, Mingjia Wen, Yufeng Int J Clin Pract Research Article The aim of this study is to evaluate the value of the triglyceride-glucose (TyG) index and the risk of large artery atherosclerotic (LAA) stroke. Information on general demographic and clinical characteristics, magnetic resonance angiography (MRA) examination, and blood biochemical index determination were obtained. Based on age stratification, three models to evaluate the odds ratio (OR) and the 95% confidence interval (95% CI) were employed to determine the correlation between the TyG index and the risk of LAA stroke. The most effective TyG index threshold in predicting a high risk of LAA stroke was identified using receiver operating characteristic (ROC) curve analysis. Logistic regression verified the association between the risk of LAA stroke and the TyG index. Both with and without age stratification, logistic regression analysis showed that the TyG index was a significant predictor of the occurrence of LAA stroke (P < 0.05). The maximum Youden index for determining a high risk of LAA stroke was found at a TyG index of 4.60. The area under the ROC curve was 0.69 (95% CI: 0.646–0.742, P < 0.05), sensitivity was 78.0%, and specificity was 63.4%. An elevated TyG index was remarkably associated with a high risk of LAA stroke. Hindawi 2022-10-11 /pmc/articles/PMC9578805/ /pubmed/36304978 http://dx.doi.org/10.1155/2022/5191581 Text en Copyright © 2022 Mingfei Jiang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Mingfei
Wu, Huan
Zhang, Huiping
Su, Fan
Cao, Lei
Ren, Xia
Tatenda, Grace
Hu, Jian
Cheng, Mingjia
Wen, Yufeng
Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke
title Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke
title_full Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke
title_fullStr Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke
title_full_unstemmed Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke
title_short Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke
title_sort association between the triglyceride-glucose index and the risk of large artery atherosclerotic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578805/
https://www.ncbi.nlm.nih.gov/pubmed/36304978
http://dx.doi.org/10.1155/2022/5191581
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