SN-38 Sensitizes BRCA-Proficient Ovarian Cancers to PARP Inhibitors through Inhibiting Homologous Recombination Repair

As a multifunctional protein posttranslational modification enzyme in eukaryotic cells, Poly-ADP-ribose polymerase (PARP) acts as a DNA damage sensor, which helps to repair DNA damage through recruiting repair proteins to the DNA break sites. PARP inhibitors offer a significant clinical benefit for...

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Detalles Bibliográficos
Autores principales: Lin, Shengbin, Tian, Jiaxin, He, Qiang, Yang, Minyi, Chen, Zuyang, Belogurov, Alexey A., Li, Xiao, Zhang, Fan, Liu, Yongzhu, Chen, Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578876/
https://www.ncbi.nlm.nih.gov/pubmed/36267463
http://dx.doi.org/10.1155/2022/7243146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578876/
https://www.ncbi.nlm.nih.gov/pubmed/36267463
http://dx.doi.org/10.1155/2022/7243146

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