Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine

Protein tyrosine phosphatases (PTPs) are critical regulators of cellular signal transduction that catalyze the hydrolytic dephosphorylation of phosphotyrosine in substrate proteins. Among several conserved features in classical PTP domains are an active-site cysteine residue that is necessary for ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Yarnall, Matthew T.N., Kim, Sean H., Korntner, Samuel, Bishop, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578986/
https://www.ncbi.nlm.nih.gov/pubmed/36275931
http://dx.doi.org/10.1016/j.bbrep.2022.101370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578986/
https://www.ncbi.nlm.nih.gov/pubmed/36275931
http://dx.doi.org/10.1016/j.bbrep.2022.101370

Ejemplares similares