Antileukemic activity of YPN-005, a CDK7 inhibitor, inducing apoptosis through c-MYC and FLT3 suppression in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive blood cancer with a high rate of relapse associated with adverse survival outcomes, especially in elderly patients. An aberrant expression of cyclin dependent kinase 7 (CDK7) is associated with poor outcomes and CDK7 inhibition has showed antitumor activ...

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Detalles Bibliográficos
Autores principales: Koo, Bon-Kwan, Choi, Eun-Ji, Hur, Eun-Hye, Moon, Ju Hyun, Kim, Ji Yun, Park, Han-Seung, Choi, Yunsuk, Lee, Jung-Hee, Lee, Kyoo-Hyung, Choi, Eun Kyung, Kim, Jinhwan, Lee, Je-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579003/
https://www.ncbi.nlm.nih.gov/pubmed/36276757
http://dx.doi.org/10.1016/j.heliyon.2022.e11004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579003/
https://www.ncbi.nlm.nih.gov/pubmed/36276757
http://dx.doi.org/10.1016/j.heliyon.2022.e11004

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