Structural and functional studies of legumain–mycocypin complexes revealed a competitive, exosite-regulated mode of interaction

Under pathophysiologic conditions such as Alzheimer’s disease and cancer, the endolysosomal cysteine protease legumain was found to translocate to the cytosol, the nucleus, and the extracellular space. These noncanonical localizations demand for a tight regulation of legumain activity, which is in p...

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Detalles Bibliográficos
Autores principales: Elamin, Tasneem, Santos, Naiá P., Briza, Peter, Brandstetter, Hans, Dall, Elfriede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579014/
https://www.ncbi.nlm.nih.gov/pubmed/36116553
http://dx.doi.org/10.1016/j.jbc.2022.102502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579014/
https://www.ncbi.nlm.nih.gov/pubmed/36116553
http://dx.doi.org/10.1016/j.jbc.2022.102502

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