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Structural and functional studies of legumain–mycocypin complexes revealed a competitive, exosite-regulated mode of interaction
Under pathophysiologic conditions such as Alzheimer’s disease and cancer, the endolysosomal cysteine protease legumain was found to translocate to the cytosol, the nucleus, and the extracellular space. These noncanonical localizations demand for a tight regulation of legumain activity, which is in p...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579014/ https://www.ncbi.nlm.nih.gov/pubmed/36116553 http://dx.doi.org/10.1016/j.jbc.2022.102502 |