Telomerase-targeting compounds Imetelstat and 6-thio-dG act synergistically with chemotherapy in high-risk neuroblastoma models

BACKGROUND: The majority of high-risk neuroblastomas harbor telomerase activity, and telomerase-interacting compounds, such as 6-thio-2’-deoxyguanosine (6-thio-dG), have been found to impair the growth of telomerase-positive neuroblastoma cell lines. It has remained unclear, however, how such drugs...

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Detalles Bibliográficos
Autores principales: Fischer-Mertens, Janina, Otte, Felix, Roderwieser, Andrea, Rosswog, Carolina, Kahlert, Yvonne, Werr, Lisa, Hellmann, Anna-Maria, Berding, Maya, Chiu, Bill, Bartenhagen, Christoph, Fischer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579108/
https://www.ncbi.nlm.nih.gov/pubmed/35953764
http://dx.doi.org/10.1007/s13402-022-00702-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579108/
https://www.ncbi.nlm.nih.gov/pubmed/35953764
http://dx.doi.org/10.1007/s13402-022-00702-8

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