Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutations

PURPOSE: Although epidermal growth factor receptor (EGFR)-activating mutations in non-small cell lung cancer (NSCLC) usually show sensitivity to first-generation EGFR-tyrosine kinase inhibitors (TKIs), most patients relapse because of drug resistance. Heat shock protein 27 (HSP27) has been reported...

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Detalles Bibliográficos
Autores principales: Choi, Seul-Ki, Kim, Minsuh, Lee, Haeseung, Kwon, Youngjoo, Cha, Hyuk-Jin, Jang, Se Jin, Na, Younghwa, Lee, Yun-Sil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579113/
https://www.ncbi.nlm.nih.gov/pubmed/35931945
http://dx.doi.org/10.1007/s13402-022-00696-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579113/
https://www.ncbi.nlm.nih.gov/pubmed/35931945
http://dx.doi.org/10.1007/s13402-022-00696-3

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