Network biology analysis of P23H rhodopsin interactome identifies protein and mRNA quality control mechanisms

Rhodopsin is essential for phototransduction, and many rhodopsin mutations cause heritable retinal degenerations. The P23H rhodopsin variant generates a misfolded rhodopsin protein that photoreceptors quickly target for degradation by mechanisms that are incompletely understood. To gain insight into...

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Detalles Bibliográficos
Autores principales: Kim, Kyle, Safarta, Lance A., Chiang, Wei-Chieh J., Coppinger, Judith A., Lee, Eun-Jin, Lin, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579138/
https://www.ncbi.nlm.nih.gov/pubmed/36258031
http://dx.doi.org/10.1038/s41598-022-22316-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579138/
https://www.ncbi.nlm.nih.gov/pubmed/36258031
http://dx.doi.org/10.1038/s41598-022-22316-8

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