Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair

Developing an effective binder for a specific ubiquitin (Ub) chain is a promising approach for modulating various biological processes with potential applications in drug discovery. Here, we combine the Random Non-standard Peptides Integrated Discovery (RaPID) method and chemical protein synthesis t...

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Detalles Bibliográficos
Autores principales: Vamisetti, Ganga B., Saha, Abhishek, Huang, Yichao J., Vanjari, Rajeshwer, Mann, Guy, Gutbrod, Julia, Ayoub, Nabieh, Suga, Hiroaki, Brik, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579194/
https://www.ncbi.nlm.nih.gov/pubmed/36257952
http://dx.doi.org/10.1038/s41467-022-33808-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579194/
https://www.ncbi.nlm.nih.gov/pubmed/36257952
http://dx.doi.org/10.1038/s41467-022-33808-6

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