Differential effects of metformin‐mediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial

Metformin has been shown to repress transcription of the bile salt export pump (BSEP) in human primary hepatocytes. The primary objective of this study was to assess the effect of oral metformin on the human pharmacokinetics (PKs) of two BSEP probe substrates: pravastatin and chenodeoxycholic acid (...

Descripción completa

Detalles Bibliográficos
Autores principales: Metry, Melissa, Krug, Samuel A., Karra, Vijaya Kumari, Kane, Maureen A., Fink, Jeffrey C., Shu, Yan, Wang, Hongbing, Polli, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579400/
https://www.ncbi.nlm.nih.gov/pubmed/35899436
http://dx.doi.org/10.1111/cts.13375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579400/
https://www.ncbi.nlm.nih.gov/pubmed/35899436
http://dx.doi.org/10.1111/cts.13375

Ejemplares similares