Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen

[Image: see text] The high mobility group box 1 (HMGB1), which is released during acute acetaminophen (APAP) overdose, is thought to mediate a subsequent immune response, particularly hepatic infiltration of macrophages. The redox behavior of HMGB1 and the proteoforms of HMGB1 present in oxidative e...

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Detalles Bibliográficos
Autores principales: Pirnie, Ross, Gillespie, Kevin P., Weng, Liwei, Mesaros, Clementina, Blair, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580022/
https://www.ncbi.nlm.nih.gov/pubmed/35922039
http://dx.doi.org/10.1021/acs.chemrestox.2c00161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580022/
https://www.ncbi.nlm.nih.gov/pubmed/35922039
http://dx.doi.org/10.1021/acs.chemrestox.2c00161

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