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Partial peptide dissociation and binding groove plasticity in two major histocompatibility complex class I alleles – differences between alleles versus force field and sampling effects

Major histocompatibility complex class I (MHC I) reports a cell's health status by presenting antigenic peptides inside its binding groove. However, MHC I binding grooves can differ largely in their plasticity, from binding grooves that are conformationally stable by themselves to those that re...

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Detalles Bibliográficos
Autores principales: Wingbermühle, Sebastian, Schäfer, Lars V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580618/
https://www.ncbi.nlm.nih.gov/pubmed/36321080
http://dx.doi.org/10.1039/d2ra05324a