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Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity

BACKGROUND: Gonadal toxicity following chemotherapy is an important issue among the population of young cancer survivors. The inhibitor of DNA topoisomerase I, irinotecan (CPT-11), is widely used for several cancer types. However, little is known about the effect of irinotecan on the fertility of bo...

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Detalles Bibliográficos
Autores principales: Levi, Mattan, Ben-Aharon, Irit, Shalgi, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580821/
https://www.ncbi.nlm.nih.gov/pubmed/36303648
http://dx.doi.org/10.3389/frph.2022.812053