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Improving peptide-protein docking with AlphaFold-Multimer using forced sampling

Protein interactions are key in vital biological processes. In many cases, particularly in regulation, this interaction is between a protein and a shorter peptide fragment. Such peptides are often part of larger disordered regions in other proteins. The flexible nature of peptides enables the rapid...

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Detalles Bibliográficos
Autores principales: Johansson-Åkhe, Isak, Wallner, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580857/
https://www.ncbi.nlm.nih.gov/pubmed/36304330
http://dx.doi.org/10.3389/fbinf.2022.959160