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The Importance of Weakly Co-Evolving Residue Networks in Proteins is Revealed by Visual Analytics
Small changes in a protein’s core packing produce changes in function, and even small changes in function bias species fitness and survival. Therefore individually deleterious mutations should be evolutionarily coupled with compensating mutations that recover fitness. Co-evolving pairs of mutations...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580873/ https://www.ncbi.nlm.nih.gov/pubmed/36304294 http://dx.doi.org/10.3389/fbinf.2022.836526 |