Cargando…

Investigating the molecular mechanism of iguratimod act on SLE using network pharmacology and molecular docking analysis

Objective: Iguratimod (IGU) is a novel small disease-modifying compound widely used in Asia for the treatment of rheumatic diseases. IGU is a methane sulfonanilide. We applied network pharmacology to investigate the pharmacological mechanisms of IGU act on SLE. Methods: We used PharmMapper, UniProt,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Huiqiong, Chen, Shuai, Lu, Xiaoping, Yan, Zhenbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580962/ https://www.ncbi.nlm.nih.gov/pubmed/36304300 http://dx.doi.org/10.3389/fbinf.2022.932114

Ejemplares similares

Investigation of the potential mechanism of the Shugan Xiaozhi decoction for the treatment of nonalcoholic fatty liver disease based on network pharmacology, molecular docking and molecular dynamics simulation
por: Yang, Rong, et al.
Publicado: (2022)

Utilizing network pharmacology and molecular docking to explore the underlying mechanism of Guizhi Fuling Wan in treating endometriosis
por: Wang, Haoxian, et al.
Publicado: (2021)

Investigating the Molecular Mechanism of Xijiao Dihuang Decoction for the Treatment of SLE Based on Network Pharmacology and Molecular Docking Analysis
por: Wei, Fangzhi, et al.
Publicado: (2022)

Active ingredients and molecular targets of Taraxacum mongolicum against hepatocellular carcinoma: network pharmacology, molecular docking, and molecular dynamics simulation analysis
por: Zheng, Yanfeng, et al.
Publicado: (2022)

Integrated network pharmacology and molecular docking approaches to reveal the synergistic mechanism of multiple components in Venenum Bufonis for ameliorating heart failure
por: Ren, Wei, et al.
Publicado: (2020)

Uncovering the mechanism of Ge-Gen-Qin-Lian decoction for treating ulcerative colitis based on network pharmacology and molecular docking verification
por: Xu, Lin, et al.
Publicado: (2021)

Exploration of the molecular targets and mechanisms of suxiao xintong dropping pills for myocardial infarction by network pharmacology method
por: Chen, Daqiu, et al.
Publicado: (2021)

Network pharmacology to investigate the pharmacological mechanisms of muscone in Xingnaojing injections for the treatment of severe traumatic brain injury
por: Liu, Zhuohang, et al.
Publicado: (2021)

Constitution of a comprehensive phytochemical profile and network pharmacology based investigation to decipher molecular mechanisms of Teucrium polium L. in the treatment of type 2 diabetes mellitus
por: Kutluay, Vahap Murat, et al.
Publicado: (2020)

Utilizing network pharmacology and experimental validation to investigate the underlying mechanism of phellodendrine on inflammation
por: Hu, Lili, et al.
Publicado: (2022)

Investigating the multi-target pharmacological mechanism of danhong injection acting on unstable angina by combined network pharmacology and molecular docking
por: Guo, Siyu, et al.
Publicado: (2020)

Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking
por: Simeon, Saw, et al.
Publicado: (2016)

Molecular modeling, simulation and docking of Rv1250 protein from Mycobacterium tuberculosis
por: Choudhary, Sumita, et al.
Publicado: (2023)

Network pharmacology- and molecular docking-based investigation of the therapeutic potential and mechanism of daucosterol against multiple myeloma
por: Zeng, Junquan, et al.
Publicado: (2023)

Potential Targets and Mechanisms of Jiedu Quyu Ziyin Decoction for Treating SLE-GIOP: Based on Network Pharmacology and Molecular Docking
por: Li, Jie, et al.
Publicado: (2023)

Identification of key genes and multiple molecular pathways of metastatic process in prostate cancer
por: Guo, Lihuang, et al.
Publicado: (2019)

Analysis of the role and mechanism of EGCG in septic cardiomyopathy based on network pharmacology
por: Wu, Ji, et al.
Publicado: (2022)

Determining novel candidate anti-hepatocellular carcinoma drugs using interaction networks and molecular docking between drug targets and natural compounds of SiNiSan
por: Zhang, Qin, et al.
Publicado: (2021)

Binding interactions of epididymal protease inhibitor and semenogelin-1: a homology modeling, docking and molecular dynamics simulation study
por: Shan, Changyu, et al.
Publicado: (2019)

A Molecular Docking Study of Human STEAP2 for the Discovery of New Potential Anti-Prostate Cancer Chemotherapeutic Candidates
por: Ongaba, Timothy, et al.
Publicado: (2022)

Exploring the therapeutic mechanisms of Gleditsiae Spina acting on pancreatic cancer via network pharmacology, molecular docking and molecular dynamics simulation
por: Duan, Hongtao, et al.
Publicado: (2023)

Network subgraph-based approach for analyzing and comparing molecular networks
por: Huang, Chien-Hung, et al.
Publicado: (2022)

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation
por: Yan, Fei, et al.
Publicado: (2021)

Study on the mechanism of Danshen-Guizhi drug pair in the treatment of ovarian cancer based on network pharmacology and in vitro experiment
por: Qin, Chongzhen, et al.
Publicado: (2022)

Network Pharmacology, Molecular Docking, and Molecular Dynamic-Based Investigation on the Mechanism of Compound Chrysanthemum in the Treatment of Asthenopia
por: Qiu, Junjie, et al.
Publicado: (2022)

Dissecting molecular network structures using a network subgraph approach
por: Huang, Chien-Hung, et al.
Publicado: (2020)

Exploring the mechanism of cordycepin combined with doxorubicin in treating glioblastoma based on network pharmacology and biological verification
por: Chen, Jing, et al.
Publicado: (2022)

Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation
por: Huang, Lili, et al.
Publicado: (2023)

Application of network pharmacology in the study of mechanism of Chinese medicine in the treatment of ulcerative colitis: A review
por: Zheng, Shihao, et al.
Publicado: (2022)

Quality Assessment of Protein Docking Models Based on Graph Neural Network
por: Han, Ye, et al.
Publicado: (2021)

Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target
por: Vlachakis, Dimitrios, et al.
Publicado: (2013)

Exploring the mechanism of Danggui Buxue Decoction in regulating atherosclerotic disease network based on integrated pharmacological methods
por: Xu, Hao, et al.
Publicado: (2021)

Regulatory mechanism of Scutellaria baicalensis Georgi on bone cancer pain based on network pharmacology and experimental verification
por: Wang, Aitao, et al.
Publicado: (2022)

Uncovering the relationship and mechanisms of Tartary buckwheat (Fagopyrum tataricum) and Type II diabetes, hypertension, and hyperlipidemia using a network pharmacology approach
por: Lu, Chao-Long, et al.
Publicado: (2017)

Investigating the molecular mechanism of Compound Danshen Dropping Pills for the treatment of epilepsy by utilizing network pharmacology and molecular docking technology
por: Huang, Dan, et al.
Publicado: (2022)

Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (−)-Guaiol Against Lung Adenocarcinoma
por: Zeng, Yaoying, et al.
Publicado: (2022)

Exploring mechanisms of Chaihu-Shugan-San against liver fibrosis by integrated multi-omics and network pharmacology approach
por: Xie, Zhihao, et al.
Publicado: (2022)

InterPepRank: Assessment of Docked Peptide Conformations by a Deep Graph Network
por: Johansson-Åkhe, Isak, et al.
Publicado: (2021)

Molecular mechanisms of Huanglian jiedu decoction on ulcerative colitis based on network pharmacology and molecular docking
por: Yang, Jing, et al.
Publicado: (2022)

Designing of the N-ethyl-4-(pyridin-4-yl)benzamide based potent ROCK1 inhibitors using docking, molecular dynamics, and 3D-QSAR
por: Ghosh, Suparna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qd63sc7l62peer49nq173jckp4