SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy

Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as Alzheimer’s disease and frontotemporal dementia. The alternative s...

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Detalles Bibliográficos
Autores principales: Muñiz, Javier Andrés, Facal, Carolina Lucía, Urrutia, Leandro, Clerici-Delville, Ramiro, Damianich, Ana, Ferrario, Juan E., Falasco, Germán, Avale, María Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581281/
https://www.ncbi.nlm.nih.gov/pubmed/36277399
http://dx.doi.org/10.3389/fbioe.2022.951384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581281/
https://www.ncbi.nlm.nih.gov/pubmed/36277399
http://dx.doi.org/10.3389/fbioe.2022.951384

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