“Rogue” neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury – studies in human, macaque and rat LPS-inflammation models

BACKGROUND AND OBJECTIVE: The correlation (Rs > 0.7) of neutrophils expressing the dual endothelin1/signal peptide receptor (DEspR+CD11b+/CD66b+) with severity of hypoxemia (SF-ratio) and multi-organ failure (SOFA-score) in patients with acute respiratory distress syndrome (ARDS) suggest the hypo...

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Detalles Bibliográficos
Autores principales: Carstensen, Saskia, Müller, Meike, Tan, Glaiza L. A., Pasion, Khristine Amber, Hohlfeld, Jens M., Herrera, Victoria L. M., Ruiz-Opazo, Nelson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581391/
https://www.ncbi.nlm.nih.gov/pubmed/36275710
http://dx.doi.org/10.3389/fimmu.2022.1008390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581391/
https://www.ncbi.nlm.nih.gov/pubmed/36275710
http://dx.doi.org/10.3389/fimmu.2022.1008390

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