Markov state modelling reveals heterogeneous drug-inhibition mechanism of Calmodulin

Calmodulin (CaM) is a calcium sensor which binds and regulates a wide range of target-proteins. This implicitly enables the concentration of calcium to influence many downstream physiological responses, including muscle contraction, learning and depression. The antipsychotic drug trifluoperazine (TF...

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Detalles Bibliográficos
Autores principales: Westerlund, Annie M., Sridhar, Akshay, Dahl, Leo, Andersson, Alma, Bodnar, Anna-Yaroslava, Delemotte, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581412/
https://www.ncbi.nlm.nih.gov/pubmed/36206305
http://dx.doi.org/10.1371/journal.pcbi.1010583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581412/
https://www.ncbi.nlm.nih.gov/pubmed/36206305
http://dx.doi.org/10.1371/journal.pcbi.1010583

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