Fuzzy supertertiary interactions within PSD-95 enable ligand binding

The scaffold protein PSD-95 links postsynaptic receptors to sites of presynaptic neurotransmitter release. Flexible linkers between folded domains in PSD-95 enable a dynamic supertertiary structure. Interdomain interactions within the PSG supramodule, formed by PDZ3, SH3, and Guanylate Kinase domain...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamilton, George L, Saikia, Nabanita, Basak, Sujit, Welcome, Franceine S, Wu, Fang, Kubiak, Jakub, Zhang, Changcheng, Hao, Yan, Seidel, Claus AM, Ding, Feng, Sanabria, Hugo, Bowen, Mark E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581536/
https://www.ncbi.nlm.nih.gov/pubmed/36069777
http://dx.doi.org/10.7554/eLife.77242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581536/
https://www.ncbi.nlm.nih.gov/pubmed/36069777
http://dx.doi.org/10.7554/eLife.77242

Ejemplares similares