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Fuzzy supertertiary interactions within PSD-95 enable ligand binding

The scaffold protein PSD-95 links postsynaptic receptors to sites of presynaptic neurotransmitter release. Flexible linkers between folded domains in PSD-95 enable a dynamic supertertiary structure. Interdomain interactions within the PSG supramodule, formed by PDZ3, SH3, and Guanylate Kinase domain...

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Detalles Bibliográficos
Autores principales:	Hamilton, George L, Saikia, Nabanita, Basak, Sujit, Welcome, Franceine S, Wu, Fang, Kubiak, Jakub, Zhang, Changcheng, Hao, Yan, Seidel, Claus AM, Ding, Feng, Sanabria, Hugo, Bowen, Mark E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581536/ https://www.ncbi.nlm.nih.gov/pubmed/36069777 http://dx.doi.org/10.7554/eLife.77242

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