Cargando…

HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids

Human organoids could facilitate research of complex and currently incurable neuropathologies, such as age-related macular degeneration (AMD) which causes blindness. Here, we establish a human retinal organoid system reproducing several parameters of the human retina, including some within the macul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Völkner, Manuela, Wagner, Felix, Steinheuer, Lisa Maria, Carido, Madalena, Kurth, Thomas, Yazbeck, Ali, Schor, Jana, Wieneke, Stephanie, Ebner, Lynn J. A., Del Toro Runzer, Claudia, Taborsky, David, Zoschke, Katja, Vogt, Marlen, Canzler, Sebastian, Hermann, Andreas, Khattak, Shahryar, Hackermüller, Jörg, Karl, Mike O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581928/ https://www.ncbi.nlm.nih.gov/pubmed/36261438 http://dx.doi.org/10.1038/s41467-022-33848-y

Ejemplares similares

Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts
por: Carido, Madalena, et al.
Publicado: (2023)

Mouse Retinal Organoid Growth and Maintenance in Longer-Term Culture
por: Völkner, Manuela, et al.
Publicado: (2021)

Transplanted human cones incorporate into the retina and function in a murine cone degeneration model
por: Gasparini, Sylvia J., et al.
Publicado: (2022)

multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data
por: Canzler, Sebastian, et al.
Publicado: (2020)

MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium
por: Almedawar, Seba, et al.
Publicado: (2020)

Morpho‐Rheological Fingerprinting of Rod Photoreceptors Using Real‐Time Deformability Cytometry
por: Santos‐Ferreira, Tiago, et al.
Publicado: (2019)

A Multi-Omics Analysis of Mucosal-Associated-Invariant T Cells Reveals Key Drivers of Distinct Modes of Activation
por: Schubert, Kristin, et al.
Publicado: (2021)

Regulation of HBEGF by Micro-RNA for Survival of Developing Human Trophoblast Cells
por: Jain, Chandni V., et al.
Publicado: (2016)

HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss
por: Shin, Clifford H., et al.
Publicado: (2017)

Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
por: Park, Seung-Ho, et al.
Publicado: (2022)

MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis
por: Zhu, Yingchun, et al.
Publicado: (2023)

Outer Segment Formation of Transplanted Photoreceptor Precursor Cells
por: Eberle, Dominic, et al.
Publicado: (2012)

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo
por: Zhou, Zhen Ni, et al.
Publicado: (2013)

SOX2 Promotes Brain Metastasis of Breast Cancer by Upregulating the Expression of FSCN1 and HBEGF
por: Xiao, Weikai, et al.
Publicado: (2020)

Biochemical and genomic identification of novel biomarkers in progressive sarcoidosis: HBEGF, eNAMPT, and ANG-2
por: Casanova, Nancy G., et al.
Publicado: (2022)

Modeling inducible neuropathologies of the retina with differential phenotypes in organoids
por: Völkner, Manuela, et al.
Publicado: (2023)

The fungal snoRNAome
por: Canzler, Sebastian, et al.
Publicado: (2018)

Three-Dimensional Neuroepithelial Culture from Human Embryonic Stem Cells and Its Use for Quantitative Conversion to Retinal Pigment Epithelium
por: Zhu, Yu, et al.
Publicado: (2013)

NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice
por: Sasaki, Keita, et al.
Publicado: (2015)

Eckol Alleviates Intestinal Dysfunction during Suckling-to-Weaning Transition via Modulation of PDX1 and HBEGF
por: Lee, Sang In, et al.
Publicado: (2020)

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion
por: Sethuraman, Aarti, et al.
Publicado: (2018)

Identification of HBEGF+ fibroblasts in the remission of rheumatoid arthritis by integrating single-cell RNA sequencing datasets and bulk RNA sequencing datasets
por: Chen, Nachun, et al.
Publicado: (2022)

THE RENEWAL OF PHOTORECEPTOR CELL OUTER SEGMENTS
por: Young, Richard W.
Publicado: (1967)

Spontaneous Regeneration of Human Photoreceptor Outer Segments
por: Horton, Jonathan C., et al.
Publicado: (2015)

A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropathy
por: Papagregoriou, Gregory, et al.
Publicado: (2012)

CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis
por: Yi, Lei, et al.
Publicado: (2021)

AI for predicting chemical-effect associations at the chemical universe level—deepFPlearn
por: Schor, Jana, et al.
Publicado: (2022)

Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler
por: Noack, Florian, et al.
Publicado: (2022)

Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646/EGFR in Human Trabecular Meshwork Cells
por: Shen, Wencui, et al.
Publicado: (2020)

THE OSMOTIC BEHAVIOR OF ROD PHOTORECEPTOR OUTER SEGMENT DISCS
por: Heller, Joram, et al.
Publicado: (1971)

Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies—the role of HAS2, SHB and HBEGF
por: Ebert, Karolin, et al.
Publicado: (2022)

The Distribution of the Photoreceptor Outer Segment Length in a Healthy Population
por: Maden, Gamze, et al.
Publicado: (2017)

Kif17 phosphorylation regulates photoreceptor outer segment turnover
por: Lewis, Tylor R., et al.
Publicado: (2018)

Light-Induced Length Shrinkage of Rod Photoreceptor Outer Segments
por: Lu, Yiming, et al.
Publicado: (2018)

The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium
por: Spencer, William J., et al.
Publicado: (2023)

s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand–foot skin reaction that can be reversed by nicotinamide
por: Luo, Peihua, et al.
Publicado: (2020)

MiR-376c-3p targets heparin-binding EGF-like growth factor (HBEGF) to inhibit proliferation and invasion in medullary thyroid carcinoma cells
por: Bai, Ning, et al.
Publicado: (2019)

The Effect of Altered Mucin1, FGF2, and HBEGF Gene Expression at The Ectopic Implantation Site and Endometrial Tissues in The Tubal Pregnancy Pathogenesis: A Case-Control Study
por: Noghrehalipour, Nadia, et al.
Publicado: (2023)

Exosomal hsa_circ_000200 as a potential biomarker and metastasis enhancer of gastric cancer via miR-4659a/b-3p/HBEGF axis
por: Huang, Xiao-juan, et al.
Publicado: (2023)

IFT20 is required for opsin trafficking and photoreceptor outer segment development
por: Keady, Brian T., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2ijd964fffuntiahb46qtj0hop