The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε

DNA polymerase ε (Polε) is a key enzyme for DNA replication in eukaryotes. Recently it was shown that the catalytic domain of yeast Polε (Polε(CD)) contains a [4Fe-4S] cluster located at the base of the processivity domain (P-domain) and coordinated by four conserved cysteines. In this work, we show...

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Detalles Bibliográficos
Autores principales: Lisova, Alisa E., Baranovskiy, Andrey G., Morstadt, Lucia M., Babayeva, Nigar D., Stepchenkova, Elena I., Tahirov, Tahir H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581978/
https://www.ncbi.nlm.nih.gov/pubmed/36261579
http://dx.doi.org/10.1038/s41598-022-21550-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581978/
https://www.ncbi.nlm.nih.gov/pubmed/36261579
http://dx.doi.org/10.1038/s41598-022-21550-4

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