Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice

The hydrolysis of xenobiotic glucuronides by gut bacterial glucuronidases reactivates previously detoxified compounds resulting in severe gut toxicity for the host. Selective bacterial β-glucuronidase inhibitors can mitigate this toxicity but their impact on wider host metabolic processes has not be...

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Detalles Bibliográficos
Autores principales: Letertre, Marine P. M., Bhatt, Aadra P., Harvey, Michael, Nicholson, Jeremy K., Wilson, Ian D., Redinbo, Matthew R., Swann, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581996/
https://www.ncbi.nlm.nih.gov/pubmed/36261446
http://dx.doi.org/10.1038/s41598-022-21518-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581996/
https://www.ncbi.nlm.nih.gov/pubmed/36261446
http://dx.doi.org/10.1038/s41598-022-21518-4

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