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The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans
Metabolic diseases often share common traits, including accumulation of unfolded proteins in the endoplasmic reticulum (ER). Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage which weakens with age. Here, we show that Caenorhabditis elegans fed a bacterial die...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582010/ https://www.ncbi.nlm.nih.gov/pubmed/36261415 http://dx.doi.org/10.1038/s41467-022-33630-0 |