Cargando…
ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans
Altered bone morphogenetic protein (BMP) signaling is associated with many musculoskeletal diseases. However, it remains unknown whether BMP dysfunction has direct contribution to debilitating pain reported in many of these disorders. Here, we identified a novel neuropathic pain phenotype in patient...
Autores principales: | Yu, Xiaobing, Ton, Amy N., Niu, Zejun, Morales, Blanca M., Chen, Jiadong, Braz, Joao, Lai, Michael H., Barruet, Emilie, Liu, Hongju, Cheung, Kin, Ali, Syed, Chan, Tea, Bigay, Katherine, Ho, Jennifer, Nikolli, Ina, Hansberry, Steven, Wentworth, Kelly, Kriegstein, Arnold, Basbaum, Allan, Hsiao, Edward C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582048/ https://www.ncbi.nlm.nih.gov/pubmed/35442931 http://dx.doi.org/10.1097/j.pain.0000000000002656 |
Ejemplares similares
-
Modeling the ACVR1(R206H) mutation in human skeletal muscle stem cells
por: Barruet, Emilie, et al.
Publicado: (2021) -
MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function
por: Barruet, Emilie, et al.
Publicado: (2020) -
Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
por: Yu, Xiaobing, et al.
Publicado: (2020) -
Contribution of colony-stimulating factor 1 to neuropathic pain
por: Yu, Xiaobing, et al.
Publicado: (2021) -
The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling
por: Barruet, Emilie, et al.
Publicado: (2016)