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Sec61 complex/translocon: The role of an atypical ER Ca(2+)-leak channel in health and disease

The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import in the ER during translation. Surprisingly, a completely different function...

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Detalles Bibliográficos
Autores principales: Parys, Jan B., Van Coppenolle, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582130/
https://www.ncbi.nlm.nih.gov/pubmed/36277220
http://dx.doi.org/10.3389/fphys.2022.991149