Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist

Mas-related G protein-coupled receptor-X2 (MRGPRX2) expressed on mast cells (MCs) contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) approved drugs such as the neuromuscular blocking agent, rocuronium. In addition, activation of MRGPRX2 by the neuropeptide su...

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Detalles Bibliográficos
Autores principales: Bawazir, Maram, Amponnawarat, Aetas, Hui, Yvonne, Oskeritzian, Carole A., Ali, Hydar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582160/
https://www.ncbi.nlm.nih.gov/pubmed/36275683
http://dx.doi.org/10.3389/fimmu.2022.1033794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582160/
https://www.ncbi.nlm.nih.gov/pubmed/36275683
http://dx.doi.org/10.3389/fimmu.2022.1033794

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