Cargando…

Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist

Mas-related G protein-coupled receptor-X2 (MRGPRX2) expressed on mast cells (MCs) contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) approved drugs such as the neuromuscular blocking agent, rocuronium. In addition, activation of MRGPRX2 by the neuropeptide su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bawazir, Maram, Amponnawarat, Aetas, Hui, Yvonne, Oskeritzian, Carole A., Ali, Hydar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582160/ https://www.ncbi.nlm.nih.gov/pubmed/36275683 http://dx.doi.org/10.3389/fimmu.2022.1033794

Ejemplares similares

Murepavadin, a Small Molecule Host Defense Peptide Mimetic, Activates Mast Cells via MRGPRX2 and MrgprB2
por: Amponnawarat, Aetas, et al.
Publicado: (2021)

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2
por: Thapaliya, Monica, et al.
Publicado: (2022)

MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants
por: Chompunud Na Ayudhya, Chalatip, et al.
Publicado: (2021)

GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells
por: Thapaliya, Monica, et al.
Publicado: (2023)

Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells
por: Solís-López, A., et al.
Publicado: (2017)

Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization
por: Chompunud Na Ayudhya, Chalatip, et al.
Publicado: (2021)

Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells
por: Chaki, Shaswati, et al.
Publicado: (2022)

Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells
por: Lazki-Hagenbach, Pia, et al.
Publicado: (2021)

Overexpression of FcεRI on Bone Marrow Mast Cells, but Not MRGPRX2, in Clonal Mast Cell Disorders With Wasp Venom Anaphylaxis
por: Elst, Jessy, et al.
Publicado: (2022)

Elevated, FcεRI‐dependent MRGPRX2 expression on basophils in chronic urticaria
por: Bartko, Ewa A., et al.
Publicado: (2022)

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production
por: Hata, Daisuke, et al.
Publicado: (1998)

Negative Regulation of FcεRI-mediated Degranulation by CD81
por: Fleming, Tony J., et al.
Publicado: (1997)

P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice
por: Yoshida, Kazuki, et al.
Publicado: (2022)

Eucalyptus oil reduces allergic reactions and suppresses mast cell degranulation by downregulating IgE-FcεRI signalling
por: Nakamura, Tomoya, et al.
Publicado: (2020)

Water Extract of Senecio scandens Buch.-Ham Ameliorates Pruritus by Inhibiting MrgprB2 Receptor
por: Ye, Fan, et al.
Publicado: (2022)

Coaggregation of FcεRI with FcγRIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells
por: Ekoff, Maria, et al.
Publicado: (2006)

FcεRI: A Master Regulator of Mast Cell Functions
por: Nagata, Yuka, et al.
Publicado: (2022)

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation
por: Ogawa, Kana, et al.
Publicado: (2014)

Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1
por: Ryu, Kunhi, et al.
Publicado: (2022)

Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2
por: Yao, Ciyu, et al.
Publicado: (2023)

Observing Fcεri Signaling from the Inside of the Mast Cell Membrane
por: Wilson, Bridget S., et al.
Publicado: (2000)

Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
por: Ra, Chisei, et al.
Publicado: (2012)

The Role Played by Mitochondria in FcεRI-Dependent Mast Cell Activation
por: Chelombitko, Maria A., et al.
Publicado: (2020)

Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol Signalosome
por: Draberova, Lubica, et al.
Publicado: (2015)

Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2
por: Franke, Kristin, et al.
Publicado: (2021)

Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics
por: Schwartz, Samantha L., et al.
Publicado: (2017)

Corrigendum: The Role Played by Mitochondria in FcϵRI-Dependent Mast Cell Activation
por: Chelombitko, Maria A., et al.
Publicado: (2020)

New Mechanistic Advances in FcεRI-Mast Cell–Mediated Allergic Signaling
por: Li, Yang, et al.
Publicado: (2022)

Rcan1 negatively regulates FcεRI-mediated signaling and mast cell function
por: Yang, Yong Jun, et al.
Publicado: (2009)

Cigarette Smoke Suppresses the Surface Expression of c-kit and FcεRI on Mast Cells
por: Givi, M. E., et al.
Publicado: (2013)

Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation
por: Phong, Binh L., et al.
Publicado: (2015)

FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes
por: Lecce, Mario, et al.
Publicado: (2020)

Kaempferol Suppresses the Activation of Mast Cells by Modulating the Expression of FcεRI and SHIP1
por: Nagata, Kazuki, et al.
Publicado: (2023)

IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation
por: Choi, Young-Ae, et al.
Publicado: (2023)

Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses
por: Callahan, Brianna N., et al.
Publicado: (2020)

An Interaction Library for the FcεRI Signaling Network
por: Chylek, Lily A., et al.
Publicado: (2014)

Chemoinformatic Analysis of Selected Cacalolides from Psacalium decompositum (A. Gray) H. Rob. & Brettell and Psacalium peltatum (Kunth) Cass. and Their Effects on FcεRI-Dependent Degranulation in Mast Cells
por: Castillo-Arellano, Jorge Iván, et al.
Publicado: (2018)

Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11
por: Sayama, Koichi, et al.
Publicado: (2002)

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT
por: Wilson, Bridget S., et al.
Publicado: (2001)

Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell–mediated allergic response
por: Wang, Di, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_c15lpu9m4rpl2qtfe7hellg7re