The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist

Inhibition of cJun is established as a promising therapeutic approach, particularly in cancer. We recently developed the “transcription block survival” (TBS) screening platform to derive functional peptide antagonists of transcription factor activity by ablating their ability to bind to cognate DNA....

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Detalles Bibliográficos
Autores principales: Brennan, Andrew, Leech, James T., Kad, Neil M., Mason, Jody M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582194/
https://www.ncbi.nlm.nih.gov/pubmed/36274790
http://dx.doi.org/10.1016/j.xcrp.2022.101077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582194/
https://www.ncbi.nlm.nih.gov/pubmed/36274790
http://dx.doi.org/10.1016/j.xcrp.2022.101077

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