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The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist
Inhibition of cJun is established as a promising therapeutic approach, particularly in cancer. We recently developed the “transcription block survival” (TBS) screening platform to derive functional peptide antagonists of transcription factor activity by ablating their ability to bind to cognate DNA....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582194/ https://www.ncbi.nlm.nih.gov/pubmed/36274790 http://dx.doi.org/10.1016/j.xcrp.2022.101077 |