BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2

Lysosomes receive extracellular and intracellular cholesterol and redistribute it throughout the cell. Cholesterol egress from lysosomes is critical for cholesterol homeostasis, and its failure underlies the pathogenesis of genetic disorders such as Niemann-Pick C (NPC) disease. Here we report that...

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Detalles Bibliográficos
Autores principales: Anderson, Jacob, Walker, Gerard, Pu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582633/
https://www.ncbi.nlm.nih.gov/pubmed/35653304
http://dx.doi.org/10.1091/mbc.E21-11-0595-T

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582633/
https://www.ncbi.nlm.nih.gov/pubmed/35653304
http://dx.doi.org/10.1091/mbc.E21-11-0595-T

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