Molecular dynamics identifies semi-rigid domains in the PD-1 checkpoint receptor bound to its natural ligand PD-L1

Cells in danger of being erroneously attacked by leucocytes express PD-L1 on their surface. These cells activate PD-1 on attacking leucocytes and send them to death, thus curbing erroneous, autoimmune attack. Unfortunately, cancer cells exploit this mechanism: By expressing PD-L1, they guard themsel...

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Detalles Bibliográficos
Autores principales: Kenn, Michael, Karch, Rudolf, Tomasiak, Lisa, Cibena, Michael, Pfeiler, Georg, Koelbl, Heinz, Schreiner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582661/
https://www.ncbi.nlm.nih.gov/pubmed/36277392
http://dx.doi.org/10.3389/fbioe.2022.838129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582661/
https://www.ncbi.nlm.nih.gov/pubmed/36277392
http://dx.doi.org/10.3389/fbioe.2022.838129

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