GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

G protein-coupled receptor (GPCR) kinase 2 (GRK2), which phosphorylates agonist-occupied GPCRs to promote their desensitization, has been investigated as an attractive therapeutic target for cardiovascular and metabolic diseases. Several GRK2-targeted inhibition strategies have been reported includi...

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Detalles Bibliográficos
Autores principales: Thapaliya, Monica, Amponnawarat, Aetas, Tesmer, John J. G., Ali, Hydar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583242/
https://www.ncbi.nlm.nih.gov/pubmed/36275707
http://dx.doi.org/10.3389/fimmu.2022.1032497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583242/
https://www.ncbi.nlm.nih.gov/pubmed/36275707
http://dx.doi.org/10.3389/fimmu.2022.1032497

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