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GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

G protein-coupled receptor (GPCR) kinase 2 (GRK2), which phosphorylates agonist-occupied GPCRs to promote their desensitization, has been investigated as an attractive therapeutic target for cardiovascular and metabolic diseases. Several GRK2-targeted inhibition strategies have been reported includi...

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Detalles Bibliográficos
Autores principales:	Thapaliya, Monica, Amponnawarat, Aetas, Tesmer, John J. G., Ali, Hydar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583242/ https://www.ncbi.nlm.nih.gov/pubmed/36275707 http://dx.doi.org/10.3389/fimmu.2022.1032497

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