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Systematic pattern analyses of Vδ2(+) TCRs reveal that shared “public” Vδ2(+) γδ T cell clones are a consequence of rearrangement bias and a higher expansion status
BACKGROUND: Vγ9Vδ2(+) T cells are a major innate T cell subset in human peripheral blood. Their Vδ2(+) VDJ-rearrangements are short and simple in the fetal thymus and gradually increase in diversity and CDR3 length along with development. So-called “public” versions of Vδ2(+) TCRs are shared among i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583675/ https://www.ncbi.nlm.nih.gov/pubmed/36275749 http://dx.doi.org/10.3389/fimmu.2022.960920 |