Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart

Insulin and insulin-like growth factor 1 (IGF1) signaling is transduced by insulin receptor substrate 1 (IRS1) and IRS2. To elucidate physiological and redundant roles of insulin and IGF1 signaling in adult hearts, we generated mice with inducible cardiomyocyte-specific deletion of insulin and IGF1...

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Detalles Bibliográficos
Autores principales: Riehle, Christian, Weatherford, Eric T., McCarty, Nicholas S., Seei, Alec, Jaishy, Bharat P., Manivel, Rajkumar, Galuppo, Paolo, Allamargot, Chantal, Hameed, Tariq, Boudreau, Ryan L., Bauersachs, Johann, Weiss, Robert M., Abel, E. Dale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583714/
https://www.ncbi.nlm.nih.gov/pubmed/36125265
http://dx.doi.org/10.1128/mcb.00163-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583714/
https://www.ncbi.nlm.nih.gov/pubmed/36125265
http://dx.doi.org/10.1128/mcb.00163-22

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