Cargando…

Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart

Insulin and insulin-like growth factor 1 (IGF1) signaling is transduced by insulin receptor substrate 1 (IRS1) and IRS2. To elucidate physiological and redundant roles of insulin and IGF1 signaling in adult hearts, we generated mice with inducible cardiomyocyte-specific deletion of insulin and IGF1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riehle, Christian, Weatherford, Eric T., McCarty, Nicholas S., Seei, Alec, Jaishy, Bharat P., Manivel, Rajkumar, Galuppo, Paolo, Allamargot, Chantal, Hameed, Tariq, Boudreau, Ryan L., Bauersachs, Johann, Weiss, Robert M., Abel, E. Dale
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583714/ https://www.ncbi.nlm.nih.gov/pubmed/36125265 http://dx.doi.org/10.1128/mcb.00163-22

Ejemplares similares

Expansion of CD10(neg) neutrophils and CD14(+)HLA-DR(neg/low) monocytes driving proinflammatory responses in patients with acute myocardial infarction
por: Fraccarollo, Daniela, et al.
Publicado: (2021)

Human iPS Cell-Derived Insulin Producing Cells Form Vascularized Organoids under the Kidney Capsules of Diabetic Mice
por: Raikwar, Sudhanshu P., et al.
Publicado: (2015)

Of mice and men: models and mechanisms of diabetic cardiomyopathy
por: Riehle, Christian, et al.
Publicado: (2018)

Small animal models of heart failure
por: Riehle, Christian, et al.
Publicado: (2019)

Association of moderately elevated trimethylamine N-oxide with cardiovascular risk: is TMAO serving as a marker for hepatic insulin resistance
por: DiNicolantonio, James J, et al.
Publicado: (2019)

Distorting the sarcomere
por: Campbell, Kenneth S.
Publicado: (2010)

Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer
por: Amutha, Periyasamy, et al.
Publicado: (2017)

Manipulating insulin signaling to enhance mosquito reproduction
por: Arik, Anam J, et al.
Publicado: (2009)

In vivo Sarcomere Lengths and Sarcomere Elongations Are Not Uniform across an Intact Muscle
por: Moo, Eng Kuan, et al.
Publicado: (2016)

Formin’ muscle sarcomeres
por: Short, Ben
Publicado: (2012)

Active Viscoelasticity of Sarcomeres
por: Nguyen, Khoi D., et al.
Publicado: (2018)

Force produced after stretch in sarcomeres and half-sarcomeres isolated from skeletal muscles
por: Minozzo, Fábio C., et al.
Publicado: (2013)

Insulin Inhibits Cardiac Contractility by Inducing a G(i)-Biased β(2)-Adrenergic Signaling in Hearts
por: Fu, Qin, et al.
Publicado: (2014)

Genetic ablation of fibroblast activation protein alpha attenuates left ventricular dilation after myocardial infarction
por: Hoffmann, Daniel B., et al.
Publicado: (2021)

Signalling in sarcomeres in development and disease
por: van Eldik, W., et al.
Publicado: (2013)

Breaking sarcomeres by in vitro exercise
por: Orfanos, Zacharias, et al.
Publicado: (2016)

Sarcomere Dysfunction in Nemaline Myopathy
por: de Winter, Josine M., et al.
Publicado: (2017)

Key inflammatory mechanisms underlying heart failure
por: Riehle, C., et al.
Publicado: (2019)

Insulin Sensitivity among Indian Diabetics
por: Gupta, Nitya Nand, et al.
Publicado: (1947)

Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Karnataka cohort of the A(1)chieve study
por: Deshpande, Neeta, et al.
Publicado: (2013)

Efficacy of mineralocorticoid receptor antagonism in the acute myocardial infarction phase: eplerenone versus spironolactone
por: Fraccarollo, Daniela, et al.
Publicado: (2015)

Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing
por: Fraccarollo, Daniela, et al.
Publicado: (2019)

THU267 A Novel In Vitro Assay Correlates Insulin Receptor Autoantibodies To Fasting Insulin In Type B Insulin Resistance
por: Abel, Brent, et al.
Publicado: (2023)

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
por: Young, Paul, et al.
Publicado: (2001)

Prediction and visualization data for the interpretation of sarcomeric and non-sarcomeric DNA variants found in patients with hypertrophic cardiomyopathy
por: Bottillo, Irene, et al.
Publicado: (2016)

Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin
por: Matheu, Victor, et al.
Publicado: (2005)

Conformational Dynamics of Insulin
por: Hua, Qing-Xin, et al.
Publicado: (2011)

Sarcomeric Gene Expression and Contractility in Myofibroblasts
por: Mayer, D.C. Ghislaine, et al.
Publicado: (1997)

The Sarcomeric Z-Disc and Z-Discopathies
por: Knöll, Ralph, et al.
Publicado: (2011)

Roles of Titin in the Structure and Elasticity of the Sarcomere
por: Tskhovrebova, Larissa, et al.
Publicado: (2010)

The Expressions and Mechanisms of Sarcomeric Proteins in Cancers
por: Yang, Xiaojing, et al.
Publicado: (2020)

The M-band: The underestimated part of the sarcomere()
por: Lange, Stephan, et al.
Publicado: (2020)

Cardiac sarcomere mechanics in health and disease
por: Crocini, Claudia, et al.
Publicado: (2021)

Cardiac Sarcomere Signaling in Health and Disease
por: Martin, Ashley A., et al.
Publicado: (2022)

Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function
por: Shymotiuk, Ivanna, et al.
Publicado: (2023)

Clinical Pharmacology of Fast-Acting Insulin Aspart Versus Insulin Aspart Measured as Free or Total Insulin Aspart and the Relation to Anti-Insulin Aspart Antibody Levels in Subjects with Type 1 Diabetes Mellitus
por: Haahr, Hanne, et al.
Publicado: (2018)

Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells
por: Liu, Siming, et al.
Publicado: (2009)

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
por: Jazbutyte, Virginija, et al.
Publicado: (2012)

The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling
por: Galuppo, Paolo, et al.
Publicado: (2017)

The Definition of Sarcomeric and Non-Sarcomeric Gene Mutations in Hypertrophic Cardiomyopathy Patients: A Multicenter Diagnostic Study Across Türkiye
por: Oktay, Veysel, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_295rnt1cqeloe4rpise908p4c1