Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases

Genome-wide association studies (GWASs) of eye disorders have identified hundreds of genetic variants associated with ocular disease. However, the vast majority of these variants are noncoding, making it challenging to interpret their function. Here we present a joint single-cell atlas of gene expre...

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Detalles Bibliográficos
Autores principales: Wang, Sean K., Nair, Surag, Li, Rui, Kraft, Katerina, Pampari, Anusri, Patel, Aman, Kang, Joyce B., Luong, Christy, Kundaje, Anshul, Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584034/
https://www.ncbi.nlm.nih.gov/pubmed/36277849
http://dx.doi.org/10.1016/j.xgen.2022.100164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584034/
https://www.ncbi.nlm.nih.gov/pubmed/36277849
http://dx.doi.org/10.1016/j.xgen.2022.100164

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