LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS

Introduction: Sepsis impaired vascular integrity results in multiple organ failure. Circulating lactate level is positively correlated with sepsis-induced mortality. We investigated whether lactate plays a role in causing endothelial barrier dysfunction in sepsis. Methods: Polymicrobial sepsis was i...

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Detalles Bibliográficos
Autores principales: Fan, Min, Yang, Kun, Wang, Xiaohui, Zhang, Xia, Xu, Jingjing, Tu, Fei, Gill, P. Spencer, Ha, Tuanzhu, Williams, David L., Li, Chuanfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Basic Science Aspects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584042/
https://www.ncbi.nlm.nih.gov/pubmed/36256626
http://dx.doi.org/10.1097/SHK.0000000000001983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584042/
https://www.ncbi.nlm.nih.gov/pubmed/36256626
http://dx.doi.org/10.1097/SHK.0000000000001983

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