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LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS

Introduction: Sepsis impaired vascular integrity results in multiple organ failure. Circulating lactate level is positively correlated with sepsis-induced mortality. We investigated whether lactate plays a role in causing endothelial barrier dysfunction in sepsis. Methods: Polymicrobial sepsis was i...

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Detalles Bibliográficos
Autores principales:	Fan, Min, Yang, Kun, Wang, Xiaohui, Zhang, Xia, Xu, Jingjing, Tu, Fei, Gill, P. Spencer, Ha, Tuanzhu, Williams, David L., Li, Chuanfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Basic Science Aspects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584042/ https://www.ncbi.nlm.nih.gov/pubmed/36256626 http://dx.doi.org/10.1097/SHK.0000000000001983

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